ATLAS OF MULTILINEAGE STEM CELL DIFFERENTIATION REVEALS TMEM88 AS A DEVELOPMENTAL REGULATOR OF BLOOD PRESSURE

Atlas of multilineage stem cell differentiation reveals TMEM88 as a developmental regulator of blood pressure

Abstract Pluripotent stem cells provide a scalable approach to analyse molecular regulation of cell differentiation across developmental lineages.Here, we engineer barcoded induced Pharmaceutical Accessories pluripotent stem cells to generate an atlas of multilineage differentiation from pluripotency, encompassing an eight-day time course with modu

read more

Anaplastic Thyroid Carcinoma: A ceRNA Analysis Pointed to a Crosstalk between SOX2, TP53, and microRNA Biogenesis

It has been suggested that cancer stem cells (CSC) may play a central role in oncogenesis, especially in undifferentiated tumours.Anaplastic thyroid carcinoma (ATC) has characteristics suggestive of a tumour enriched in CSC.Previous studies suggested that the stem cell factor Home SOX2 has a preeminent hierarchical role in determining the character

read more


Recruitment of PfSET2 by RNA polymerase II to variant antigen encoding loci contributes to antigenic variation in P. falciparum.

Histone modifications are important regulators of gene expression in all eukaryotes.In Plasmodium falciparum, these epigenetic Skirt marks regulate expression of genes involved in several aspects of host-parasite interactions, including antigenic variation.While the identities and genomic positions of many histone modifications have now been catalo

read more